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Sharma, J. V. C.
- Analgesic and Anti-inflammatory Activity of Methanolic Extract of Leaves of Quisqualis indica
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Journal of Natural Remedies, Vol 12, No 2 (2012), Pagination: 135-140Abstract
The present study was designed to evaluate the analgesic and anti-inflammatory activity of methanolic extract of Quisqualis indica (MEQI) leaves in rodents. The peripheral analgesic activity of methanolic extract of Quisqualis indica leaves (MEQI; 200 and 400 mg/kg) was studied using acetic acid-induced writhing test and central analgesic activity of MEQI was studied using hot-plate method in mice. Anti-Inflammatory activity of MEQI (200 and 400 mg/kg) was studied in carragenin induced paw edema in rats. MEQI significantly decreased the writhing movements in acetic acid-induced writhing test and increased the reaction time in hot-plate test in mice. MEQI also showed significant anti-Inflammatory activity in carragenin induced paw edema by reducing paw volume in rats. From our study, we concluded that MEQI has potential analgesic and anti-inflammatory activities.Keywords
Analgesic, Antiinflammatory, Quisqualis indica- Development and Validation for Estimation of Abiraterone acetate in Bulk and Pharmaceutical Dosage Form by UPLC
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1 Department of Pharmaceutical Analysis, Joginpally B.R Pharmacy College, Yenkapally, Moinabad, R.R. Dist. Telangana, IN
1 Department of Pharmaceutical Analysis, Joginpally B.R Pharmacy College, Yenkapally, Moinabad, R.R. Dist. Telangana, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3029-3032Abstract
A simple, Robust, stability indicated method was developed for the estimation of Abiraterone by RP-UPLC technique. Chromatographic conditions used are, stationary phase SB C8 100 x 3.0 mm, 1.8. Mobile phase 0.01N NaH2PO4: Acetonitrile in the ratio of 60:40v/v and flow rate were maintained at 0.3 ml/min, detection wave length was 235 nm, and column temperature was set to 30oC. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 0.6 for repeatability and 1.1 for intermediate precision. LOD and LOQ are 0.09μg/ml and 0.27μg/ml respectively. Degradation studies of Abiraterone were done, in all conditions and it is within the acceptable range.Keywords
UPLC, Abiraterone Acetate, Mobile Phase, Method Development.References
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